Selected Publications
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Iyer, H., Talbot, W.S. 2024. Chloride transporter ClC-7 is essential for phagocytic clearance by microglia.
J Cell Sci
137(4): jcs261616. doi: 10.1242/jcs.261616. PMID: 38294065; PMCID: PMC10911276.
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Iyer, H., Shen, K., Meireles, A.M., Talbot, W.S. 2022. A lysosomal regulatory circuit essential for the development and function of microglia.
Sci Adv
8(35):eabp8321. doi: 10.1126/sciadv.abp8321. PMID: 36044568; PMCID: PMC9432849.
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Gan, L., Seki, A., Shen, K., Iyer, H., Han, K., Hayer, A., Wollman, R., Ge, X., Lin, J.R., Dey, G., Talbot, W.S., Meyer, T. 2019. The lysosomal GPCR-like protein regulates Rag and mTORC1 localization and activity.
Nat Cell Biol
21(5):614-626. doi: 10.1038/s41556-019-0321-6. PMID: 31036939; PMCID: PMC6649673.
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Meireles, A.M., Shen, K., Zoupi, L., Iyer, H., Bouchard, E.L., Williams, A., Talbot, W.S. 2018. The lysosomal transcription factor TFEB regulates myelination downstream of the Rag-Ragulator complex.
Dev Cell
47(3):319-330. doi: 10.1016/j.devcel.2018.10.003. PMID: 30399334; PMCID: PMC6250074.
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Iyer, H., Issigonis, M., Sharma, P.P., Extavour, C.G., P.A. Newmark. 2016. A premeiotic function for boule in the planarian Schmidtea mediterranea.
Proc Natl Acad Sci USA
113(25): E3509–18. doi: 10.1073/pnas.1521341113. PMID: 27330085; PMCID: PMC4922153.
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Iyer, H., Collins III, J.J., P.A. Newmark. 2016. NF-YB regulates spermatogonial stem cell self-renewal and proliferation in the planarian Schmidtea mediterranea.
PLoS Genet
12(6): e1006109. doi: 10.1371/journal.pgen.1006109. PMID: 27304889; PMCID: PMC4909293.
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Collins III, J.J., Wendt, G.R., Iyer, H., P. A. Newmark. 2016. Stem cell progeny contribute to the schistosome host-parasite interface.
eLife.
5:243. doi: 10.7554/eLife.12473. PMID: 27003592; PMCID: PMC4841766.
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Collins III, J.J., Wang, B., Lambrus, B.G., Tharp, M., Iyer, H., and P. A. Newmark. 2013. Adult somatic stem cells in the human parasite, Schistosoma mansoni.
Nature
494: 476-479. doi: 10.1038/nature11924. PMID: 23426263; PMCID: PMC3586782.
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Other Publications
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Naik, M., Raichurkar, A., Bandodkar, B.S., Varun, B.V., Bhat, S., Kalkhambkar, R., Murugan, K., Menon, R., Bhat, J., Paul, B., Iyer, H., et al. 2015. Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors.
J Med Chem.
58(2): 753-66. doi: 10.1021/jm5012947. PMID: 25486447.
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Balasubramanian, V., Solapure, S., Iyer, H., et al. 2013. Bactericidal activity and mechanism of action of AZD5847, a novel oxazolidinone for treatment of tuberculosis.
Antimicrob Agents Chemother.
58(1): 495-502. doi: 10.1128/AAC.01903-13. PMID: 24189255; PMCID: PMC3910779.
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Gising, J., Nilsson, M.T., Odell, L.R., Yahiaoui, S., Lindh, M., Iyer, H., et al. 2012. Trisubstituted imidazoles as Mycobacterium tuberculosis glutamine synthetase inhibitors.
J Med Chem.
55(6): 2894-8. doi: 10.1021/jm201212h. PMID: 22369127; PMCID: PMC3381009.
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Andaloussi, M., Lindh, M., Björkelid, C., Suresh, S., Wieckowska, A., Iyer, H., et al. 2011. Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis.
Bioorg Med Chem Lett.
21(18): 5403-7. doi: 10.1016/j.bmcl.2011.07.005. PMID: 21824775.
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Andaloussi, M., Henriksson, L.M., Więckowska, A., Lindh, M., Björkelid, C., Larsson, A.M., Suresh, S., Iyer, H., et al. 2011. Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.
J Med Chem.
54(14): 4964-76. doi: 10.1021/jm2000085. PMID: 21678907.
[Pubmed]
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