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Selected Publications

  • Gallman, K., Ricemeyer, E., Rastogi A., X. M., Mendez Scolari, E., Duboue, E.R., Rohner, N., Iyer, H., Warren, W.C., Keene, A.C. 2026. A comparative brain atlas of Mexican cavefish identifies naturally-occurring changes in cellular composition and gene expression.. bioRxiv doi: 10.64898/2026.05.12.723532.
  • Mendez Scolari, E., Amanyi, O.K., Rastogi, A., Duboue, E.R., Keene, A.C., Iyer, H. 2026. Evolved differences in microglial cell biology between surface and cave populations of Astyanax mexicanus. bioRxiv doi: 10.64898/2026.04.11.717796.
  • Iyer, H., Benoist, C., Bilbo, S.D., Boulanger, L.M., Burton, M.D., Daniels, B.P., Deczkowska, A., Flajnik, M.F., Gareau, M.G., Grace, P.M., Irazoqui, J.E., Reynolds, T.L., Rosi, S., Salinas, I., Schaefer, A., Sokol, C.L., Williams, D.W., and Klein, R.S. 2025. Systems Neuroimmunology: Current Bottlenecks, Research Priorities and Future Directions. Nat. Immunol. 2025. 26(3):325-329. doi: 10.1038/s41590-025-02092-z. PMID: 39939753; PMCID: PMC12016954. [Pubmed]
  • Iyer, H., Talbot, W.S. 2024. Chloride transporter ClC-7 is essential for phagocytic clearance by microglia. J. Cell Sci. 2024. 137(4): jcs261616. doi: 10.1242/jcs.261616. PMID: 38294065; PMCID: PMC10911276. [PDF] [Pubmed]
  • Iyer, H., Shen, K., Meireles, A.M., Talbot, W.S. 2022. A lysosomal regulatory circuit essential for the development and function of microglia. Sci. Adv. 2022. 8(35):eabp8321. doi: 10.1126/sciadv.abp8321. PMID: 36044568; PMCID: PMC9432849. [PDF] [Pubmed]
  • Gan, L., Seki, A., Shen, K., Iyer, H., Han, K., Hayer, A., Wollman, R., Ge, X., Lin, J.R., Dey, G., Talbot, W.S., Meyer, T. 2019. The lysosomal GPCR-like protein regulates Rag and mTORC1 localization and activity. Nat. Cell Biol. 2019. 21(5):614-626. doi: 10.1038/s41556-019-0321-6. PMID: 31036939; PMCID: PMC6649673. [PDF] [Pubmed]
  • Meireles, A.M., Shen, K., Zoupi, L., Iyer, H., Bouchard, E.L., Williams, A., Talbot, W.S. 2018. The lysosomal transcription factor TFEB regulates myelination downstream of the Rag-Ragulator complex. Dev. Cell 2018. 47(3):319-330. doi: 10.1016/j.devcel.2018.10.003. PMID: 30399334; PMCID: PMC6250074. [PDF] [Pubmed]


Other Publications

  • Iyer, H., Issigonis, M., Sharma, P.P., Extavour, C.G., P.A. Newmark. 2016. A premeiotic function for boule in the planarian Schmidtea mediterranea. Proc. Natl. Acad. Sci. U.S.A. 2016. 113(25): E3509–18. doi: 10.1073/pnas.1521341113. PMID: 27330085; PMCID: PMC4922153. [PDF] [Pubmed]
  • Iyer, H., Collins III, J.J., P.A. Newmark. 2016. NF-YB regulates spermatogonial stem cell self-renewal and proliferation in the planarian Schmidtea mediterranea. PLoS Genet. 2016. 12(6): e1006109. doi: 10.1371/journal.pgen.1006109. PMID: 27304889; PMCID: PMC4909293. [PDF] [Pubmed]
  • Collins III, J.J., Wendt, G.R., Iyer, H., P. A. Newmark. 2016. Stem cell progeny contribute to the schistosome host-parasite interface. eLife 2016. 5:243. doi: 10.7554/eLife.12473. PMID: 27003592; PMCID: PMC4841766. [PDF] [Pubmed]
  • Naik, M., Raichurkar, A., Bandodkar, B.S., Varun, B.V., Bhat, S., Kalkhambkar, R., Murugan, K., Menon, R., Bhat, J., Paul, B., Iyer, H., et al. 2015. Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors. J. Med. Chem. 2015. 58(2): 753-66. doi: 10.1021/jm5012947. PMID: 25486447. [Pubmed]
  • Balasubramanian, V., Solapure, S., Iyer, H., et al. 2013. Bactericidal activity and mechanism of action of AZD5847, a novel oxazolidinone for treatment of tuberculosis. Antimicrob. Agents Chemother. 2014. 58(1): 495-502. doi: 10.1128/AAC.01903-13. PMID: 24189255; PMCID: PMC3910779. [Pubmed]
  • Collins III, J.J., Wang, B., Lambrus, B.G., Tharp, M., Iyer, H., and P. A. Newmark. 2013. Adult somatic stem cells in the human parasite, Schistosoma mansoni. Nature 2013. 494: 476-479. doi: 10.1038/nature11924. PMID: 23426263; PMCID: PMC3586782. [PDF] [Pubmed]
  • Gising, J., Nilsson, M.T., Odell, L.R., Yahiaoui, S., Lindh, M., Iyer, H., et al. 2012. Trisubstituted imidazoles as Mycobacterium tuberculosis glutamine synthetase inhibitors. J. Med. Chem. 2012. 55(6): 2894-8. doi: 10.1021/jm201212h. PMID: 22369127; PMCID: PMC3381009. [Pubmed]
  • Andaloussi, M., Lindh, M., Björkelid, C., Suresh, S., Wieckowska, A., Iyer, H., et al. 2011. Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis. Bioorg. Med. Chem. Lett. 2011. 21(18): 5403-7. doi: 10.1016/j.bmcl.2011.07.005. PMID: 21824775. [Pubmed]
  • Andaloussi, M., Henriksson, L.M., Więckowska, A., Lindh, M., Björkelid, C., Larsson, A.M., Suresh, S., Iyer, H., et al. 2011. Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase. J. Med. Chem. 2011. 54(14): 4964-76. doi: 10.1021/jm2000085. PMID: 21678907. [Pubmed]